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肌钙集蛋白/收钙素抗体
产物名称 | 英文名称 | 货号 |
肌钙集蛋白/收钙素抗体 | Calsequestrin | GOY-01K1983 |
商品属性：
英文名称: Calsequestrin
中文名:肌钙集蛋白/收钙素抗体
别 名；CASQ;
Calsequestrin 1; Calsequestrin 1 fast twitch skeletal muscle; Calsequestrin 2;
Calsequestrin 2 fast twitch cardiac muscle; Calsequestrin cardiac muscle
isoform; Calsequestrin skeletal muscle isoform; Cardiac calsequestrin 2; CASQ
1; CASQ 2; PDIB1; PDIB2; Skeletal muscle calsequestrin 1.
研究领域；心血管 信号转导 转录调节因子 结合蛋白 线粒体
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
产物应用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；40kDa
细胞定位；细胞浆 线粒体
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Calsequestrin: 75-170/396
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
The sarcoplasmic reticulum (SR) is, in part,
responsible for maintaining the level of intracellular calcium in cardiac and
skeletal muscle by storing and releasing calcium. Several intralumenal SR
calcium binding proteins have been identified, the most prominent of these is
calsequestrin. Calsequstrin is a calcium binding protein known to sequester
calcium accumulated in the sarcoplasmic reticulum of muscle cells during
relaxation and is found discretely localized to the junctional and corbular
(terminal cisternae) SR. Calsequestrin functions to localize calcium near the
junctional face of the terminal cisternae from which calcium can be released
into the cytosol via the ryanodine receptor. This protein is highly acidic
and has a large capacity and moderate to low affinity for calcium. Calsequestrin is a high-capacity, moderate
affinity, calcium-binding protein and thus acts as an internal calcium store
in muscle. The release of calcium bound to calsequestrin through a calcium
release channel triggers muscle contraction. The skeletal muscle isoform
(CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds
approximately 60 Ca(2+). |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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