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尝型电压依赖型钙通道β4抗体
产物名称 | 英文名称 | 货号 |
L型电压依赖型钙通道β4抗体 | CACNB4 | GOY-01K1155 |
商品属性：
英文名称: CACNB4
中文名:L型电压依赖型钙通道β4抗体
别 名；CAB4; L-type Ca++
CPβ4; CACB4_HUMAN; Cacnb4; CACNLB4; Calcium channel
voltage dependent beta 4 subunit; Calcium channel voltage dependent subunit
beta 4; Calcium channel voltage-dependent subunit beta 4; Dihydropyridine
sensitive L type calcium channel beta 4 subunit; EA5; EIG9; EJM; EJM4;
Voltage-dependent L-type calcium channel subunit beta-4.
研究领域；细胞生物 神经生物学 信号转导 通道蛋白
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
产物应用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理论分子量；58kDa
细胞定位；细胞浆 细胞膜
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human CACNB4/L-type Ca++ CPβ4: 301-400/520
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
Voltage-dependent calcium channels are essential
for the release of neurotransmitters. L-type (long lasting current) voltage-dependent
calcium channels are composed of four subunits: an Alpha1 subunit, a Beta
subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is
encoded by four genes, designated Beta1-Beta 4, all of which contribute to
the diversity of calcium currents and are involved in membrane trafficking of
the Beta subunit. L-type Ca++ CP Beta 4, also known as CACNB4 (Calcium
channel voltage-dependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino
acid protein that contains one SH3 domain and is expressed in ovary, brain
and smooth muscle. Functioning as one of the four components of the Beta
subunit, L-type Ca++ CP Beta 4 increases the peak calcium current in
voltage-dependent calcium channels, thereby shifting the voltage dependencies
of activation and inactivation and controlling G protein inhibition and Beta
membrane targeting. Two isoforms of L-type Ca++ CP Beta4 exist due to
alternative splicing events. The beta subunit of voltage-dependent calcium
channels contributes to the function of the calcium channel by increasing
peak calcium current, shifting the voltage dependencies of activation and
inactivation, modulating G protein inhibition and controlling the alpha-1
subunit membrane targeting. Subunit: The L-type calcium channel is composed of four
subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG. Tissue Specificity: Expressed predominantly in the cerebellum and
kidney. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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