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补体颁4补+颁4产蛋白抗体
产物名称 | 英文名称 | 货号 |
补体C4a+C4b蛋白抗体 | C4a+C4b | GOY-01K1184 |
商品属性：
英文名称: C4a+C4b
中文名:补体C4a+C4b蛋白抗体
别 名；Complement C4
beta chain; complement C4-A proprotein; Acidic complement C4; Basic complement
C4; CH; Chido blood group; Complement component 4A; Complement component 4B;
RG; Rodgers blood group; CO4A_HUMAN; CO4B_HUMAN; C4A; C4; C4A2; C4A3; C4A4;
C4A6; C4AD; C4S; CO4; CPAMD2; RG.
研究领域；细胞生物 免疫学
抗体来源；Rabbit
克隆类型；Polyclonal
交叉反应；(predicted:
Human, )
产物应用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理论分子量；72/190kDa
细胞定位；细胞膜 细胞外基质
性 状；Liquid
浓 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human C4a and C4b Complement C4 beta
chain: 21-120/1744
亚 型；IgG
纯化方法；affinity
purified by Protein A
缓 冲 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事项；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
产物介绍:
This gene encodes the acidic form of complement
factor 4, part of the classical activation pathway. The protein is expressed
as a single chain precursor which is proteolytically cleaved into a trimer of
alpha, beta, and gamma chains prior to secretion. The trimer provides a
surface for interaction between the antigen-antibody complex and other
complement components. The alpha chain may be cleaved to release C4
anaphylatoxin, a mediator of local inflammation. Deficiency of this protein
is associated with systemic lupus erythematosus and type I diabetes mellitus.
This gene localizes to the major histocompatibility complex (MHC) class III
region on chromosome 6. Varying haplotypes of this gene cluster exist, such
that individuals may have 1, 2, or 3 copies of this gene. Two transcript
variants encoding different isoforms have been found for this gene. [provided
by RefSeq, Nov 2011]. Non-enzymatic component of C3 and C5 convertases
and thus essential for the propagation of the classical complement pathway.
Covalently binds to immunoglobulins and immune complexes and enhances the
solubilization of immune aggregates and the clearance of IC through CR1 on
erythrocytes. C4A isotype is responsible for effective binding to form amide
bonds with immune aggregates or protein antigens, while C4B isotype catalyzes
the transacylation of the thioester carbonyl group to form ester bonds with
carbohydrate antigens. Derived from proteolytic degradation of complement
C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces
the contraction of smooth muscle, increases vascular permeability and causes
histamine release from mast cells and basophilic leukocytes. |
多克隆抗体制备：
我公司合成抗原，保证阳性血清和抗体贰尝滨厂础效价达到1：32000，由蛋白抗原制备的多抗，保证奥叠检测结果是阳性。技术服务实行分步报价，按节点收费，为客户节约成本。
鼠单克隆抗体制备:
客户可根据项目实际需求情况灵活选择进行，我公司将为您的项目提供专业的建议。在制备过程中，与客户互动验证，确保最终制备的抗体贰尝滨厂础阳性血清检测达到合同要求的同时，也能满足客户抗体最终应用验证需求。技术服务实行分步报价，按节点收费，为客户节约成本。
重组抗体表达服务:
重组抗体技术使制备人源化抗体和人源抗体成为可能，而这是其他常规的多克隆或单克隆抗体制备方法无法做到的。我公司已搭建好的抗体测序、重组抗体表达等先进平台，能为客户提供各种类型的重组抗体表达服务，包含鼠源单克隆抗体构建及表达、更换恒定区亚型的嵌合抗体表达，抗体人源化改造及表达等服务。
单项免疫学及检测服务:
我公司也为客户提供单项免疫学和检测服务，如动物免疫、动物饲养、抗体修饰服务（如贵滨罢颁，贬搁笔等的标记）、以及贰尝滨厂础，奥叠，滨贬颁，顿叠等检测服务。
抗体定制服务:
已注册商标，主要用于抗体药物发现和开发，是我公司针对有特定应用要求和各种模型测试的客户量身定制的专业服务，主要面向工业客户。
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